Identification of N alpha-acetyl-epsilon-(2-propenal)lysine as a urinary metabolite of malondialdehyde.

@article{Mcgirr1985IdentificationON,
  title={Identification of N alpha-acetyl-epsilon-(2-propenal)lysine as a urinary metabolite of malondialdehyde.},
  author={Larry Gordon Mcgirr and Michael Hadley and Harold H. Draper},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 29},
  pages={
          15427-31
        }
}
Although orally administered malondialdehyde (MDA), a reactive hepatotoxic and mutagenic product of lipid peroxidation, is extensively metabolized to CO2, a portion is excreted in the urine in acid labile "bound" forms. Since much of the MDA in the diet is apparently bound to protein, the metabolism of protein-bound MDA was investigated. MDA was reacted with serum albumin and fed to rats. A urinary metabolite was detected which was shown to be identical to a metabolite of the lysine-MDA… CONTINUE READING

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