Identification of Multipotent Progenitors that Emerge Prior to Hematopoietic Stem Cells in Embryonic Development

@inproceedings{Inlay2014IdentificationOM,
  title={Identification of Multipotent Progenitors that Emerge Prior to Hematopoietic Stem Cells in Embryonic Development},
  author={Matthew A Inlay and Thomas Serwold and Adriane R. Mosley and John W. Fathman and Ivan K Dimov and Jun Seita and Irving L Weissman},
  booktitle={Stem cell reports},
  year={2014}
}
Hematopoiesis in the embryo proceeds in a series of waves, with primitive erythroid-biased waves succeeded by definitive waves, within which the properties of hematopoietic stem cells (multilineage potential, self-renewal, and engraftability) gradually arise. Whereas self-renewal and engraftability have previously been examined in the embryo, multipotency has not been thoroughly addressed, especially at the single-cell level or within well-defined populations. To identify when and where clonal… CONTINUE READING
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