Identification of Multipotent Progenitors that Emerge Prior to Hematopoietic Stem Cells in Embryonic Development

@article{Inlay2014IdentificationOM,
  title={Identification of Multipotent Progenitors that Emerge Prior to Hematopoietic Stem Cells in Embryonic Development},
  author={Matthew A Inlay and Thomas Serwold and Adriane R Mosley and John W. Fathman and Ivan K Dimov and Jun Seita and Irving L. Weissman},
  journal={Stem Cell Reports},
  year={2014},
  volume={2},
  pages={457 - 472}
}
Summary Hematopoiesis in the embryo proceeds in a series of waves, with primitive erythroid-biased waves succeeded by definitive waves, within which the properties of hematopoietic stem cells (multilineage potential, self-renewal, and engraftability) gradually arise. Whereas self-renewal and engraftability have previously been examined in the embryo, multipotency has not been thoroughly addressed, especially at the single-cell level or within well-defined populations. To identify when and where… Expand
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All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac.
The relative contribution of yolk sac (YS)-derived cells to the circulating definitive hematopoietic progenitor cell (HPC) pool that seeds the fetal liver remains controversial due to the presence ofExpand
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