Identification of Multiple Serine Racemase (SRR) mRNA Isoforms and Genetic Analyses of SRR and DAO in Schizophrenia and d-Serine Levels

@article{Yamada2005IdentificationOM,
  title={Identification of Multiple Serine Racemase (SRR) mRNA Isoforms and Genetic Analyses of SRR and DAO in Schizophrenia and d-Serine Levels},
  author={Kazuo Yamada and Tetsuo Ohnishi and Kenji Hashimoto and Hisako Ohba and Yoshimi Iwayama-Shigeno and Manabu Toyoshima and Akira Okuno and Hitomi Takao and Tomoko Toyota and Yoshio Minabe and Kazuhiko Nakamura and Eiji Shimizu and Masanari Itokawa and Norio Mori and Masaomi Iyo and Takeo Yoshikawa},
  journal={Biological Psychiatry},
  year={2005},
  volume={57},
  pages={1493-1503}
}
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148 Citations
Highly Influential Citations
7
Background Citations
47
Methods Citations
11
Results Citations
12

148 Citations

A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia

Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.

Analysis of SRR genetic variants in humans identified a robust association with schizophrenia and demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.

Analysis of correlation between serum d-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes

Polymorphism in the 5′-promoter region of serine racemase gene in schizophrenia

The frequency of the genotypes showed that although the 5'-G/C SRR polymorphism is obviously not a major risk factor for schizophrenia, the modest contribution of thegenotypes as a protective or vice versa disease risk factors have to be considered further.

Correlation of functional GRIN2A gene promoter polymorphisms with schizophrenia and serum D-serine levels.

Serine racemase binds to PICK1: potential relevance to schizophrenia

This study identifies and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the D-serine synthesizing enzyme, serine racemase (SR).

Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion

Findings support a model wherein mutant DISC1 leads to SR degradation via dominant negative effects, resulting in D-serine deficiency that diminishes NMDA neurotransmission thus linking DISC 1 and NMDA pathophysiological mechanisms in mental illness.

Metabolism of the neuromodulator D-serine

An overview of the current knowledge of the metabolism of D-serine in human brain at the molecular and cellular levels, with a specific emphasis on the brain localization and regulatory pathways of D -serine, serine racemase, and D-amino acid oxidase is presented.

Metabolism of the neuromodulator d-serine

An overview of the current knowledge of the metabolism of d-serine in human brain at the molecular and cellular levels, with a specific emphasis on the brain localization and regulatory pathways of d -serine, serine racemase, and d-amino acid oxidase is presented.

Serine Racemase Knockout Mice: Neurotoxicity, Epilepsy, and Schizophrenia

The phenotypes of these SR-KO mice used as animal models of NMDAR-mediated neurotoxicity, epilepsy, and schizophrenia are reviewed and the mechanistic involvement of the SR-d-serine pathway in these neurological and psychiatric disorders is discussed.
...

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