Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity.

@article{Smaldone2004IdentificationOM,
  title={Identification of MoKA, a novel F-box protein that modulates Kr{\"u}ppel-like transcription factor 7 activity.},
  author={Silvia Smaldone and Friedrich Laub and Cindy Else and Cecilia L Dragomir and Francesco Ramirez},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 3},
  pages={1058-69}
}
KLF7, a member of the Krüppel-like transcription factor family, is believed to regulate neurogenesis and cell cycle progression. Here, a yeast two-hybrid screen for KLF7 cofactors in the developing nervous system identified a novel 140-kDa protein named MoKA, for modulator of KLF7 activity. Interaction between MoKA and KLF7 was confirmed by the in vitro glutathione S-transferase pull-down assay and by coimmunoprecipitation of the proteins overexpressed in mammalian cells. Functional assays… CONTINUE READING