Identification of MicroRNA Processing Determinants by Random Mutagenesis of Arabidopsis MIR172a Precursor

@article{Mateos2010IdentificationOM,
  title={Identification of MicroRNA Processing Determinants by Random Mutagenesis of Arabidopsis MIR172a Precursor},
  author={Julieta L Mateos and Nicolas G Bologna and Uciel Chorostecki and Javier F. Palatnik},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={49-54}
}
MicroRNAs (miRNAs) are widespread posttranscriptional regulators of gene expression. They are processed from longer primary transcripts that contain foldback structures (reviewed in). In animals, a complex formed by Drosha and DGCR8/Pasha recognizes the transition between the single-stranded RNA sequences and the stem loop to produce the first cleavage step in miRNA biogenesis. Whereas animal precursors are of uniform size and shape, their plant counterparts comprise a collection of variable… CONTINUE READING

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