Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

@article{Caruso2017IdentificationOM,
  title={Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.},
  author={P Caruso and Benjamin J. Dunmore and Duncan J Stewart and Sandra Schoors and Cl{\'a}udia Ferreira Dos Santos and Carol Perez-Iratxeta and Jessie R. Lavoie and Hui Zhang and L. -K. Long and Amanda R Flockton and Maria G. Frid and Paul D Upton and Angelo D'Alessandro and Charaka Hadinnapola and Fedir N Kiskin and Mohamad Kassem Taha and Liam A Hurst and Mark L. Ormiston and Akiko Hata and Kurt R Stenmark and Peter Carmeliet and Nicholas W Morrell},
  journal={Circulation},
  year={2017},
  volume={136 25},
  pages={2451-2467}
}
BACKGROUND Pulmonary arterial hypertension (PAH) is characterized by abnormal growth and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms underlying alterations in energy production have not been identified. METHODS Here, we examined the miRNA and proteomic profiles of blood outgrowth endothelial cells (BOECs) from patients with heritable PAH caused by mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene and patients with idiopathic PAH to… CONTINUE READING
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