Identification of Methylated Genes Associated with Aggressive Clinicopathological Features in Mantle Cell Lymphoma


BACKGROUND Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. The contribution of DNA methylation to MCL lymphomagenesis is not well known. We sought to identify epigenetically silenced genes in these tumours that might have clinical relevance. METHODOLOGY… (More)
DOI: 10.1371/journal.pone.0019736


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