Identification of Mechanosensitive Genes during Embryonic Bone Formation

  title={Identification of Mechanosensitive Genes during Embryonic Bone
  author={Niamh C. Nowlan and Patrick J. Prendergast and Paula Murphy},
  journal={PLoS Computational Biology},
  pages={1052 - 1060}
Although it is known that mechanical forces are needed for normal bone development, the current understanding of how biophysical stimuli are interpreted by and integrated with genetic regulatory mechanisms is limited. Mechanical forces are thought to be mediated in cells by "mechanosensitive" genes, but it is a challenge to demonstrate that the genetic regulation of the biological system is dependant on particular mechanical forces in vivo. We propose a new means of selecting candidate… CONTINUE READING


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