Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory.

@article{Braekeleer2011IdentificationOM,
  title={Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory.},
  author={Etienne de Braekeleer and Claus Meyer and Nathalie Douet-Guilbert and Audrey Basinko and Marie-Jos{\'e}e Le Bris and Fr{\'e}d{\'e}ric Morel and Christian Berthou and Rolf Marschalek and Claude F{\'e}rec and Marc de Braekeleer},
  journal={Molecular oncology},
  year={2011},
  volume={5 6},
  pages={555-63}
}
Chromosomal rearrangements involving the MLL gene have been associated with many different types of hematological malignancies. Fluorescent in situ hybridization with a panel of probes coupled with long distance inverse-PCR was used to identify chromosomal rearrangements involving the MLL gene. Between 1995 and 2010, 27 patients with an acute leukemia were found to have a fusion gene involving MLL. All seven ALL patients with B cell acute lymphoblastic leukemia were characterized by the MLL… CONTINUE READING