Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung.

  title={Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung.},
  author={Larisa V. Debelenko and Elizabeth Brambilla and Sunita Agarwal and Jennifer I. Swalwell and Mary Beth Kester and Irina A. Lubensky and Zhengping Zhuang and Siradanahalli C. Guru and Pachiappan Manickam and S E Olufemi and Settara C Chandrasekharappa and Judy S Crabtree and Young S. Kim and Christina Heppner and A. Lee Burns and Allen M. Spiegel and Stephen J. Marx and Lance A. Liotta and Francis S. Collins and William D Travis and Michael R. Emmert-Buck},
  journal={Human molecular genetics},
  volume={6 13},
Lung carcinoids occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). There are no well defined genetic abnormalities known to occur in these tumors. We studied 11 sporadic lung carcinoids for loss of heterozygosity (LOH) at the locus of the MEN1 gene on chromosome 11q13, and for mutations of the MEN1 gene using dideoxy fingerprinting. Additionally, a lung carcinoid from a MEN1 patient was studied. In four of 11 (36%) sporadic tumors, both copies of the… CONTINUE READING
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Localization of the multiple endocrine neoplasia type 1 (MEN 1) gene based on tumor LOH analysis

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