Identification of LAT4, a novel amino acid transporter with system L activity.

  title={Identification of LAT4, a novel amino acid transporter with system L activity.},
  author={Susanna Bodoy and Lorena Mart{\'i}n and Antonio Zorzano and Manuel Palac{\'i}n and Ra{\'u}l Est{\'e}vez and Joan Bertran},
  journal={The Journal of biological chemistry},
  volume={280 12},
System L amino acid transporters mediate the movement of bulky neutral amino acids across cell membranes. Until now three proteins that induce system L activity have been identified: LAT1, LAT2, and LAT3. The former two proteins belong to the solute carrier family 7 (SLC7), whereas the latter belongs to SLC43. In the present study we present a new cDNA, designated LAT4, which also mediates system L activity when expressed in Xenopus laevis oocytes. Human LAT4 exhibits 57% identity to human LAT3… CONTINUE READING
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