Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis.

@article{Zhu2018IdentificationOK,
  title={Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis.},
  author={Fangxiao Zhu and R. Huang and J. Li and Xiwen Liao and Yumei Huang and Y. Lai},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2018},
  volume={24},
  pages={
          7100-7108
        }
}
  • Fangxiao Zhu, R. Huang, +3 authors Y. Lai
  • Published 2018
  • Biology, Medicine
  • Medical science monitor : international medical journal of experimental and clinical research
  • BACKGROUND RUNXl plays a key regulatory role in the process of hematopoiesis and is a common target for multiple chromosomal translocations in human acute leukemia. Mutations of RUNX1 gene can lead to acute leukemia and affect the prognosis of AML patients. We aimed to identify pivotal genes and pathways involved in RUNX1-mutated patients of with acute myeloid leukemia (AML) and to explore possible molecular markers for novel therapeutic targets of the disease. MATERIAL AND METHODS The RNA… CONTINUE READING
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