Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions.

@article{Suehara2012IdentificationOK,
  title={Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions.},
  author={Yoshiyuki Suehara and Maria E. Arcila and Lu Wang and Adnan Hasanovic and Daphne Shih Wen Ang and Tatsuo Ito and Yuki Kimura and Alexander D Drilon and Udayan Guha and Valerie M Rusch and Mark G. Kris and Maureen F. Zakowski and Naiyer A Rizvi and R. Khanin and Marc Ladanyi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 24},
  pages={6599-608}
}
BACKGROUND The mutually exclusive pattern of the major driver oncogenes in lung cancer suggests that other mutually exclusive oncogenes exist. We conducted a systematic search for tyrosine kinase fusions by screening all tyrosine kinases for aberrantly high RNA expression levels of the 3' kinase domain (KD) exons relative to more 5' exons. METHODS We studied 69 patients (including five never smokers and 64 current or former smokers) with lung adenocarcinoma negative for all major mutations in… CONTINUE READING
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