Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.

  title={Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.},
  author={Lawrence S Argetsinger and Gaylon S. Campbell and Xiulan Q Yang and Bruce A. Witthuhn and Olli Silvennoinen and James N. Ihle and Christin Carter-Su},
  volume={74 2},
Growth hormone receptor (GHR) forms a complex with a tyrosine kinase, suggesting involvement of a ligand-activated tyrosine kinase in intracellular signaling by growth hormone (GH). Here we identify JAK2, a nonreceptor tyrosine kinase, as a GHR-associated tyrosine kinase. Immunological approaches were used to establish GH-dependent complex formation between JAK2 and GHR, activation of JAK2 tyrosine kinase activity, and tyrosyl phosphorylation of both JAK2 and GHR. The JAK2-GHR and JAK2… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
213 Citations
36 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 213 extracted citations


Publications referenced by this paper.
Showing 1-10 of 36 references

Differential regulation of two glucose transporters by chronic growth hormone treatment of cultured 3T3-F442A adipose cells

  • Tai, K P.-K., +4 authors Carter
  • J. Biol
  • 1990
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…