Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.

@article{Argetsinger1993IdentificationOJ,
  title={Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.},
  author={Lawrence S Argetsinger and Gaylon S. Campbell and Xiulan Q Yang and Bruce A. Witthuhn and Olli Silvennoinen and James N. Ihle and Christin Carter-Su},
  journal={Cell},
  year={1993},
  volume={74 2},
  pages={237-44}
}
Growth hormone receptor (GHR) forms a complex with a tyrosine kinase, suggesting involvement of a ligand-activated tyrosine kinase in intracellular signaling by growth hormone (GH). Here we identify JAK2, a nonreceptor tyrosine kinase, as a GHR-associated tyrosine kinase. Immunological approaches were used to establish GH-dependent complex formation between JAK2 and GHR, activation of JAK2 tyrosine kinase activity, and tyrosyl phosphorylation of both JAK2 and GHR. The JAK2-GHR and JAK2… CONTINUE READING
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