Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.

@article{Poyet2001IdentificationOI,
  title={Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.},
  author={J L Poyet and Srinivasa M. Srinivasula and Mehdi Tnani and Marjaneh Razmara and Teresa Fernandes-Alnemri and Emad S. Alnemri},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 30},
  pages={28309-13}
}
Procaspase-9 contains an NH2-terminal caspase-associated recruitment domain (CARD), which is essential for direct association with Apaf-1 and activation. Procaspase-1 also contains an NH2-terminal CARD domain, suggesting that its mechanism of activation, like that of procaspase-9, involves association with an Apaf-1-related molecule. Here we describe the identification of a human Apaf-1-related protein, named Ipaf that contains an NH2-terminal CARD domain, a central nucleotide-binding domain… CONTINUE READING
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