Identification of Interferon-Stimulated Genes with Antiretroviral Activity

  title={Identification of Interferon-Stimulated Genes with Antiretroviral Activity},
  author={Melissa Kane and Trinity M. Zang and Suzannah J. Rihn and Fengwen Zhang and Tonya Kueck and Mudathir A Alim and John W Schoggins and Charles M. Rice and Sam Wilson and Paul D Bieniasz},
  booktitle={Cell host & microbe},
Interferons (IFNs) exert their anti-viral effects by inducing the expression of hundreds of IFN-stimulated genes (ISGs). The activity of known ISGs is insufficient to account for the antiretroviral effects of IFN, suggesting that ISGs with antiretroviral activity are yet to be described. We constructed an arrayed library of ISGs from rhesus macaques and tested the ability of hundreds of individual macaque and human ISGs to inhibit early and late replication steps for 11 members of the… CONTINUE READING
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