Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses

  title={Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses},
  author={Jin Tian and Xiaoliang Hu and Dafei Liu and Hongxia Wu and Liandong Qu},
  journal={International Journal of Biological Macromolecules},
  pages={160 - 167}

Inonotus obliquus – from folk medicine to clinical use

Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms

The extracts from I. obliquus, P. igniarius, C. sinensis, and M. esculenta showed potential anti-FIV activity.

Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis

Results showed that IOP improved the condition of uterine tissues and reduced the release of pro-inflammatory cytokines, and the 16S rRNA sequencing results showed thatIOP could regulate the changes in intestinal microflora at the level of genera, possibly by changing the relative abundance of some genera.


The melanin isolated from cultivated birch fungus is similar to the melanin from naturalBirch fungus in respect of its physicochemical and antiviral properties, and is a promising substance for the developing of naturally occurring medication.

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

This review can provide significant insight into the IOPS bioactivities as their in vitro and in vivo data were summarized, and some possible mechanisms were listed.

Mushroom: a potent source of natural antiviral drugs

69 mushroom species with potent antiviral agents and mode of action against prominent viruses such as human immunodeficiency virus, influenza, herpes simplex virus, hepatitis B and C viruses, corona viruses etc are listed in this study.



A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1.

An overview of the available literature regarding the efficacy of antiviral drugs and other compounds with proven or putative activity against FHV-1, as well as a discussion of their safety in cats is provided.

Antiviral Activity of Inonotus Obliquus Fungus Extract towards Infection Caused by Hepatitis C Virus in Cell Cultures

The data indicate that the birch fungus extracts inhibit production of infective virus by porcine embryo kidney cells and antiviral effects of fungus extracts manifested after preventive and therapeutic use.

Inhibition of Japanese Encephalitis Virus Infection by the Sulfated Polysaccharide Extracts from Ulva lactuca

It is identified that the sulfated polysaccharide extracts from Ulva lactuca can inhibit JEV infection in Vero cells and effectively decrease the production of pro-inflammatory cytokines in the JEV-infected primary mixed glia cells.

Novel DL-Galactan Hybrids from the Red Seaweed Gymnogongrus Torulosus are Potent Inhibitors of Herpes Simplex Virus and Dengue Virus

A novel series of DL-galactan hybrids extracted from the red seaweed Gymnogongrus torulosus, was evaluated for its in vitro antiviral properties against herpes simplex virus type 2 (HSV-2) and dengue

Assessment of the IFN-β response to four feline caliciviruses: Infection in CRFK cells.

  • Jin TianXiaozhan Zhang Liandong Qu
  • Biology
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2015

Anti-HIV activity of extracts and compounds from algae and cyanobacteria.

This review discusses the anti-HIV activity of extracts and compounds isolated from freshwater and marine algae, and cyanobacteria, and studies using nonsulfated and sulfated homo- and heteropolysaccharides isolated from algae or other natural sources, or synthesized have revealed the mechanisms of binding of drugs to the virion.

Identification of Inonotus obliquus and Analysis of Antioxidation and Antitumor Activities of Polysaccharides

The results indicate that I. obliquus polysaccharides exhibit high antitumor and antioxidation effects, which will enable large-scale production of the poly Saccharides.