Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses

  title={Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses},
  author={Jin Tian and Xiaoliang Hu and Dafei Liu and Hongxia Wu and Liandong Qu},
  journal={International Journal of Biological Macromolecules},
  pages={160 - 167}
Abstract Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low… Expand
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Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms
The extracts from I. obliquus, P. igniarius, C. sinensis, and M. esculenta showed potential anti-FIV activity. Expand
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  • Medicine
  • Antiviral Research
  • 2020
It was shown that both nitazoxanide and mizoribine had antiviral activity in F81 cells infected with different strains of FCV and also demonstrated a synergistic effect between the two drugs. Expand
Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide.
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  • Yuxi Guo, Xuefeng Chen, Pin Gong
  • Medicine
  • International Journal of Biological Macromolecules
  • 2021
The type of anti-viral EMFs and the structural characteristics of polysaccharides to clarify the structure-activity relationship are discussed and the directly or indirectly antiviral mechanism of EMFs poly Saccharides, including virus function suppression, immune-modulatory activity, anti-inflammatory activity, regulation of population balance of gut microbiota are concluded. Expand
Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application
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69 mushroom species with potent antiviral agents and mode of action against prominent viruses such as human immunodeficiency virus, influenza, herpes simplex virus, hepatitis B and C viruses, corona viruses etc are listed in this study. Expand
Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus.
The diverse bioactive metabolites in I. obliquus possess the potential to reduce incidence of tumorigenesis in healthy people and exhibit immunomodulatory potential to restore the compromised immunity and protect against ulcerative damage of GI tract caused by chemotherapy. Expand
Biological and anticancer properties of Inonotus obliquus extracts
Abstract Inonotus obliquus (IO) has traditionally been used in folk medicine in the treatment of gastrointestinal cancer, cardiovascular disease and diabetes. The aim of our study was to evaluate theExpand
Antiviral Bioactive Compounds of Mushrooms and Their Antiviral Mechanisms: A Review
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In vitro antiviral effect of germacrone on feline calicivirus
Germacrone, one of the main constituents of volatile oil from rhizoma curcuma, was able to effectively reduce the growth of FCV strain F9 in vitro, the first report of antiviral effects of germacrone against a calicivirus. Expand
Antiviral effect of mefloquine on feline calicivirus in vitro
These results are the first report of antiviral effects of mefloquine against a calicivirus and support further in vitro and in vivo evaluation of this compound as an antiviral therapeutic for FCV. Expand
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Results suggest that these direct acting antiviral compounds, or their derivatives, warrant further investigation for clinical use in cats with FIP. Expand
Antiviral effect of lithium chloride on feline calicivirus in vitro
It is shown that lithium chloride (LiCl) effectively suppresses the replication of FCV strain F9 in Crandell-Reese feline kidney (CRFK) cells and demonstrates that LiCl might be an effective anti-FCV drug for controlling FCV disease. Expand
A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1.
An overview of the available literature regarding the efficacy of antiviral drugs and other compounds with proven or putative activity against FHV-1, as well as a discussion of their safety in cats is provided. Expand
Antiviral Activity of Inonotus Obliquus Fungus Extract towards Infection Caused by Hepatitis C Virus in Cell Cultures
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Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.
From studies on their mechanism of action, it is concluded that polysulfates exert their anti-HIV activity by shielding off the positively charged sites in the V3 loop of the viral envelope glycoprotein (gp120). Expand
Inhibition of Japanese Encephalitis Virus Infection by the Sulfated Polysaccharide Extracts from Ulva lactuca
It is identified that the sulfated polysaccharide extracts from Ulva lactuca can inhibit JEV infection in Vero cells and effectively decrease the production of pro-inflammatory cytokines in the JEV-infected primary mixed glia cells. Expand
Novel DL-Galactan Hybrids from the Red Seaweed Gymnogongrus Torulosus are Potent Inhibitors of Herpes Simplex Virus and Dengue Virus
A novel series of DL-galactan hybrids extracted from the red seaweed Gymnogongrus torulosus, was evaluated for its in vitro antiviral properties against herpes simplex virus type 2 (HSV-2) and dengueExpand
Assessment of the IFN-β response to four feline caliciviruses: Infection in CRFK cells.
  • Jin Tian, Xiaozhan Zhang, +4 authors Liandong Qu
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2015
It is found that some FCV strains cannot induce IFN-β expression in vitro, which may be a potential factor for FCV survival in cats and whether this is important in evading the host interferon response in vivo must be investigated. Expand