Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.

  title={Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.},
  author={Chikari Takeo and Kazuhiro Ikeda and Kuniko Horie-Inoue and Satoshi Inoue},
  journal={Endocrine journal},
  volume={56 1},
Estrogen has an important effect on higher brain function such as memory, learning, and emotion in which the hippocampus plays a critical role. The hippocampus expresses estrogen receptors, ER alpha and ERbeta, which are ligand-dependent transcription factors; however, the precise mechanism of estrogen action is not fully understood. We explored genes which are up-regulated by estrogen in the hippocampus using ovariectomized rat models. Microarray analysis revealed that mRNA levels of… CONTINUE READING


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