Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli.

@article{Bubnoff2011IdentificationOI,
  title={Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli.},
  author={Dagmar von Bubnoff and Marina Scheler and Helene Wilms and Rolf Fimmers and Thomas Bieber},
  journal={Journal of immunology},
  year={2011},
  volume={186 12},
  pages={
          6701-9
        }
}
Dendritic cells (DCs) can induce tolerance or immunity. We identified and characterized an IDO-expressing and an IDO-negative human DC population after stimulation by various proinflammatory stimuli. IDO expression was strongly dependent on the maturation status of the cells (CD83-positive cells only). The two DC subpopulations remained IDO positive and IDO negative, respectively, over a time period of at least 48 h. IDO enzyme activity of human DCs was highest during stimulation by strongly… CONTINUE READING
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