Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes

@inproceedings{Li2016IdentificationOH,
  title={Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes},
  author={Jia Li and Chunyong He and Lianxiang Fang and Li Yang and Zhengtao Wang},
  booktitle={International journal of molecular sciences},
  year={2016}
}
20(S)-protopanaxadiol (PPD), one of the representative aglycones of ginsenosides, has a broad spectrum of pharmacological activities. Although phase I metabolism has been investigated extensively, information regarding phase II metabolism of this compound remains to be elucidated. Here, a glucuronidated metabolite of PPD in human liver microsomes (HLMs) and rat liver microsomes (RLMs) was unambiguously identified as PPD-3-O-β-D-glucuronide by nuclear magnetic resonance spectroscopy and high… CONTINUE READING

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Identification of 20(S)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes.

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