Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

@article{Abdelmohsen2017IdentificationOH,
  title={Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1},
  author={K. Abdelmohsen and A. Panda and R. Munk and Ioannis Grammatikakis and Dawood B. Dudekula and Supriyo De and Jiyoung Kim and J. Noh and K. Kim and J. Martindale and M. Gorospe},
  journal={RNA Biology},
  year={2017},
  volume={14},
  pages={361 - 369}
}
ABSTRACT HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular RNAs (circRNAs) and impacts on their function is unknown. Here, we have identified en masse circRNAs binding HuR in human cervical carcinoma HeLa cells. One of the most prominent HuR target circRNAs was hsa_circ_0031288, renamed CircPABPN1 as it arises from the PABPN1 pre-mRNA. Further analysis revealed that HuR did not… Expand
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