Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis.

@article{Momose2002IdentificationOH,
  title={Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis.},
  author={Fumitaka Momose and Tadasuke Naito and Keiichi Yano and Seiji Sugimoto and Yuko Morikawa and Kyosuke Nagata},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 47},
  pages={
          45306-14
        }
}
Efficient transcription and replication of the influenza virus genome are dependent upon host-derived factors. Using an in vitro RNA synthesis system, we have purified and identified Hsp90 as one of the host factors that stimulate viral RNA polymerase activity. Hsp90 interacted with the PB2 subunit of the viral RNA polymerase through the amino-terminal chaperone domain and the middle region containing a highly acidic domain. The acidic middle region was also responsible for its stimulatory… CONTINUE READING
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