Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice.

@article{KimKaneyama2012IdentificationOH,
  title={Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice.},
  author={Joo-ri Kim-Kaneyama and Akira Miyauchi and Xiao Feng Lei and Shigeko Arita and Takashi Mino and Naoki Takeda and Kou Kou and Koji Eto and Takashi Yoshida and Takuro Miyazaki and Seiji Shioda and Akira Miyazaki},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2012},
  volume={10 9},
  pages={1867-74}
}
BACKGROUND Integrin αIIbβ3 plays key roles in platelet aggregation and subsequent thrombus formation. Hydrogen peroxide-inducible clone-5 (Hic-5), a member of the paxillin family, serves as a focal adhesion adaptor protein associated with αIIbβ3 at its cytoplasmic strand. OBJECTIVES Hic-5 function in αIIbβ3 activation and subsequent platelet aggregation remains unknown. To address this question, platelets from Hic-5(-/-) mice were analyzed. METHODS AND RESULTS Hic-5(-/-) mice displayed a… CONTINUE READING

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