Identification of Heregulin, a Specific Activator of p185erbB2
@article{Holmes1992IdentificationOH, title={Identification of Heregulin, a Specific Activator of p185erbB2}, author={William Evan Holmes and Mark X. Sliwkowski and Robert W. Akita and William J. Henzel and James M. Lee and John W. Park and Daniel G. Yansura and Nasrin Abadi and Helga Raab and Gail D. Lewis and H. Michael Shepard and W. J. Kuang and William l. Wood and David Norman Van Goeddel and Richard Vandlen}, journal={Science}, year={1992}, volume={256}, pages={1205 - 1210} }
The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. A 45-kilodalton protein heregulin-α (HRG-α) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the…
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Abstract.Heregulin (HRG) is a soluble secreted growth factor, which, upon binding and activation of ErbB3 and ErbB4 transmembrane receptor tyrosine kinases, is involved in cell proliferation,…
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