• DOI:10.1126/science.256.5060.1205
Corpus ID: 32783956

Identification of Heregulin, a Specific Activator of p185erbB2

@article{Holmes1992IdentificationOH,
  title={Identification of Heregulin, a Specific Activator of p185erbB2},
  author={W. Holmes and M. Sliwkowski and R. Akita and W. Henzel and J. Lee and J. Park and D. Yansura and Nasrin Abadi and H. Raab and G. Lewis and H. Shepard and W. Kuang and William l. Wood and D. Goeddel and R. Vandlen},
  journal={Science},
  year={1992},
  volume={256},
  pages={1205 - 1210}
}

• W. Holmes, M. Sliwkowski, +12 authors R. Vandlen
• Published 1992
• Biology, Medicine
• Science

The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. A 45-kilodalton protein heregulin-α (HRG-α) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the… Expand

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