Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014-2015 Influenza Season.

@article{Chambers2015IdentificationOH,
  title={Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014-2015 Influenza Season.},
  author={Benjamin S. Chambers and Kaela Parkhouse and Ted M Ross and Kevin Alby and Scott E Hensley},
  journal={Cell reports},
  year={2015},
  volume={12 1},
  pages={1-6}
}
Influenza vaccines must be updated regularly because influenza viruses continuously acquire mutations in antibody binding sites of hemagglutinin (HA). The majority of H3N2 strains circulating in the Northern Hemisphere during the 2014-2015 season are antigenically mismatched to the A/Texas/50/2012 H3N2 vaccine strain. Recent H3N2 strains possess several new HA mutations, and it is unknown which of these mutations contribute to the 2014-2015 vaccine mismatch. Here, we use reverse genetics to… CONTINUE READING
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