Identification of HLA class I-binding peptides derived from unique cancer-associated proteins by mass spectrometric analysis.

Abstract

BACKGROUND/AIM Since antigenic peptides of the cancer-associated antigens presented on human leukocyte antigen (HLA) molecules are recognized by specific cytotoxic T-lymphocytes, they have the potential to becoming effective peptide vaccines for cancer immunotherapy. MATERIALS AND METHODS Peptides binding to HLA-A*0201 and HLA-A*2402 obtained from human… (More)

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