Identification of HLA DR 7-restricted Epitopes from Human Telomerase Reverse Transcriptase Recognized by CD 4 T-Helper Cells 1

@inproceedings{Schroers2002IdentificationOH,
  title={Identification of HLA DR 7-restricted Epitopes from Human Telomerase Reverse Transcriptase Recognized by CD 4 T-Helper Cells 1},
  author={Roland Schroers and Xue Fen Huang and J{\"u}rgen Hammer and Jingwu Zhang and Si-Yi Chen},
  year={2002}
}
CD4 T cells play critical roles in initiating, regulating, and maintaining antitumor immune responses. One way to improve current tumor vaccines that mainly induce CTLs would be to activate antigen-specific CD4 T cells that recognize MHC class II restricted tumor associated antigens. Human telomerase reverse transcriptase (hTRT) is preferentially expressed by various tumors and, therefore, could be a universal tumor antigen. In this study, we used a combined approach of using the prediction… CONTINUE READING
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