Identification of HLA-A2-restricted immunogenic peptides derived from a xenogenic porcine major histocompatibility complex.

@article{Park2014IdentificationOH,
  title={Identification of HLA-A2-restricted immunogenic peptides derived from a xenogenic porcine major histocompatibility complex.},
  author={Chan-Su Park and Seungbin Im and Sukgil Song and Kwanghyun Kim and Chong Kil Lee},
  journal={Xenotransplantation},
  year={2014},
  volume={21 5},
  pages={
          465-72
        }
}
BACKGROUND Little information is available regarding the precise swine leukocyte antigen (SLA)-derived immunogenic peptides that are presented in the context of human HLA molecules. Here, we identified SLA-derived immunogenic peptides that are presented in association with human HLA-A2 molecule. METHODS The SLA-derived peptides that bind to HLA-A*0201, a representative of the A2 supertype, were predicted using a computer-assisted algorithm. The candidate peptides were synthesized, and the… CONTINUE READING
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