Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy.

@article{Ueda2010IdentificationOH,
  title={Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy.},
  author={Ryo Ueda and Kozo Ohkusu-Tsukada and Noemi Fusaki and Akio Soeda and Takeshi Kawase and Yutaka Kawakami and Masahiro Toda},
  journal={International journal of cancer},
  year={2010},
  volume={126 4},
  pages={919-29}
}
Malignant gliomas are the most aggressive human primary brain tumors and are currently incurable. Immunotherapies have the potential to target glioma and glioma stem cells (GSCs) that are resistant to conventional therapies. We previously identified SOX6 as a human glioma antigen and demonstrated that vaccination with SOX6 DNA induced cytotoxic T lymphocytes (CTLs) specific for glioma, thereby exerting therapeutic antitumor responses in glioma-bearing mice. In this study, we attempted to… CONTINUE READING