Identification of HLA-A*0201-restricted cytotoxic T lymphocyte epitope from TRAG-3 antigen.

  title={Identification of HLA-A*0201-restricted cytotoxic T lymphocyte epitope from TRAG-3 antigen.},
  author={Bo Zhu and Zhengtang Chen and Xiaoming Cheng and Zhihua Lin and Jianxiu Guo and Zhengcai Jia and Liyun Zou and Zhixin Wang and Yide Hu and Dongling Wang and Yu-zhang Wu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={9 5},
PURPOSE Identification of tumor antigen and subsequent identification of T-cell epitope from these antigens make specific immunotherapy for malignant tumor applicable. Because TRAG-3 antigen is expressed in most melanomas and 54% of non-small cell lung carcinomas and HLA-A2.1-expressing individuals cover >50% in the population of China, we aim at identifying TRAG-3-encoded peptide presented by HLA-A2.1. EXPERIMENTAL DESIGN In our study, a HLA-A2.1-restricted CTL epitope was identified by… CONTINUE READING


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