Identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicates the existence of potential asymptomatic infections.

@article{Powell2012IdentificationOH,
  title={Identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicates the existence of potential asymptomatic infections.},
  author={Timothy J. Powell and Annette Fox and Yanchun Peng and Le Thi Quynh Mai and Vu Thi Kim Lien and Nguyen Le Khanh Hang and Li-li Wang and Laurel Y-H Lee and Cameron P. Simmons and Andrew J McMichael and Jeremy J. Farrar and Brigitte A. Askonas and Tran Nhu Duong and Pham Quang Thai and Nguyen Thi Thu Yen and Sarah L Rowland-Jones and Nguyen Tran Hien and Peter Horby and Tao Dong},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={205 1},
  pages={20-7}
}
BACKGROUND Most reported human H5N1 viral infections have been severe and were detected after hospital admission. A case ascertainment bias may therefore exist, with mild cases or asymptomatic infections going undetected. We sought evidence of mild or asymptomatic H5N1 infection by examining H5N1-specific T-cell and antibody responses in a high-risk cohort in Vietnam. METHODS Peripheral blood mononuclear cells were tested using interferon-γ enzyme-linked immunospot T assays measuring the… CONTINUE READING