Identification of Genes Preferentially Expressed by Highly Virulent Piscine Streptococcus agalactiae upon Interaction with Macrophages

@inproceedings{Guo2014IdentificationOG,
  title={Identification of Genes Preferentially Expressed by Highly Virulent Piscine Streptococcus agalactiae upon Interaction with Macrophages},
  author={Chang-Ming Guo and Rong-rong Chen and Dildar Hussain Kalhoro and Zhao-fei Wang and Guang-jin Liu and Cheng-ping Lu and Yong-jie Liu},
  booktitle={PloS one},
  year={2014}
}
Streptococcus agalactiae, long recognized as a mammalian pathogen, is an emerging concern with regard to fish. In this study, we used a mouse model and in vitro cell infection to evaluate the pathogenetic characteristics of S. agalactiae GD201008-001, isolated from tilapia in China. This bacterium was found to be highly virulent and capable of inducing brain damage by migrating into the brain by crossing the blood-brain barrier (BBB). The phagocytosis assays indicated that this bacterium could… CONTINUE READING
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