Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2

  title={Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2},
  author={S. Jindadamrongwech and C. Thepparit and D. Smith},
  journal={Archives of Virology},
  • S. Jindadamrongwech, C. Thepparit, D. Smith
  • Published 2003
  • Biology, Medicine
  • Archives of Virology
  • Summary.This study sought to identify receptor elements for dengue virus serotype 2 on human liver cells (HepG2) using the viral overlay protein binding assay (VOPBA) technique and Mass Spectrometry fingerprinting. A single major and several minor virus binding bands were observed, and mass spectrometry identified a candidate binding protein for the major binding band as GRP 78 (BiP). GRP78 expression on the cell surface was confirmed, and antibodies directed against both the N and C-terminus… CONTINUE READING
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