Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2

  title={Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2},
  author={Sumalee Jindadamrongwech and Chutima Thepparit and D. R. Smith},
  journal={Archives of Virology},
Summary.This study sought to identify receptor elements for dengue virus serotype 2 on human liver cells (HepG2) using the viral overlay protein binding assay (VOPBA) technique and Mass Spectrometry fingerprinting. A single major and several minor virus binding bands were observed, and mass spectrometry identified a candidate binding protein for the major binding band as GRP 78 (BiP). GRP78 expression on the cell surface was confirmed, and antibodies directed against both the N and C-terminus… 

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