Identification of GRO1 as a critical determinant for mutant p53 gain of function.

  title={Identification of GRO1 as a critical determinant for mutant p53 gain of function.},
  author={Wensheng Yan and Xinbin Chen},
  journal={The Journal of biological chemistry},
  volume={284 18},
Mutant p53 gain of function contributes to cancer progression, increased invasion and metastasis potentials, and resistance to anticancer therapy. The ability of mutant p53 to acquire its gain of function is shown to correlate with increased expression of progrowth genes, such as c-MYC, MDR1, and NF-kappaB2. However, most of the published studies to identify mutant p53 target genes were performed in a cell system that artificially overexpresses mutant p53. Thus, it remains unclear whether such… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2016
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