Identification of G protein-coupled signaling pathways in cardiac fibroblasts: cross talk between G(q) and G(s).

@article{Meszaros2000IdentificationOG,
  title={Identification of G protein-coupled signaling pathways in cardiac fibroblasts: cross talk between G(q) and G(s).},
  author={J. Gary Meszaros and A. Gonz{\'a}lez and Y Endo-Mochizuki and Sonia Villegas and Francisco Villarreal and Laurence L. Brunton},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={278 1},
  pages={
          C154-62
        }
}
Cardiac fibroblasts (CFs) are an important cellular component of myocardial responses to injury and to hypertrophic stimuli. We studied G protein-coupled receptors to understand how CFs integrate signals that activate G(q), G(s), and G(i). We predicted that the second messenger pathways present in CFs were distinct from those in cardiac myocytes and that unique signaling interactions existed in the CFs. ANG II, bradykinin, ATP, and UTP stimulated inositol phosphate (IP) production 2.2- to 7… 
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