Identification of Functionally Segregated Sarcoplasmic Reticulum Calcium Stores in Pulmonary Arterial Smooth Muscle*

@inproceedings{Clark2010IdentificationOF,
  title={Identification of Functionally Segregated Sarcoplasmic Reticulum Calcium Stores in Pulmonary Arterial Smooth Muscle*},
  author={Jill H. Clark and Nicholas P. Kinnear and Svetlana Kalujnaia and Gordon Cramb and Sidney Fleischer and Loice H. Jeyakumar and Frank Wuytack and A Mark Evans},
  booktitle={The Journal of biological chemistry},
  year={2010}
}
In pulmonary arterial smooth muscle, Ca(2+) release from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) may induce constriction and dilation in a manner that is not mutually exclusive. We show here that the targeting of different sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPases (SERCA) and RyR subtypes to discrete SR regions explains this paradox. Western blots identified protein bands for SERCA2a and SERCA2b, whereas immunofluorescence labeling of isolated pulmonary arterial… CONTINUE READING
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H123–H131 SERCA and RyR in Smooth Muscle APRIL

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