Identification of Functional mimotopes of human Vasorin Ectodomain by Biopanning

@inproceedings{Li2018IdentificationOF,
  title={Identification of Functional mimotopes of human Vasorin Ectodomain by Biopanning},
  author={Da Li and Tianzhou Zhang and Xiqin Yang and Jie Geng and Shaohua Li Shaohua Li and Hongmei Ding and Hui Li and Anping Huang and Chaonan Wang and Leqiao Sun and Chenjun Bai and Heqiu Zhang and Jie Li and Jie Dong and Ningsheng Shao},
  booktitle={International journal of biological sciences},
  year={2018}
}
Human vasorin (VASN) as a type I transmembrane protein, is a potential biomarker of hepatocellular carcinoma, which could expedite HepG2 cell proliferation and migration significantly in vitro. The ectodomain of VASN was proteolytically released to generate soluble VASN (sVASN), which was validated to be the active form. Among several monoclonal antibodies produced against sVASN, the clone V21 was found to bind with the recombinant human sVASN (rhsVASN) with the highest affinity and specificity… CONTINUE READING

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Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 3 EXCERPTS
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