Identification of Functional Differences in Metabolic Networks Using Comparative Genomics and Constraint-Based Models

Abstract

Genome-scale network reconstructions are useful tools for understanding cellular metabolism, and comparisons of such reconstructions can provide insight into metabolic differences between organisms. Recent efforts toward comparing genome-scale models have focused primarily on aligning metabolic networks at the reaction level and then looking at differences… (More)
DOI: 10.1371/journal.pone.0034670

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