Identification of Francisella tularensis subsp. tularensis A1 and A2 infections by real-time polymerase chain reaction.

@article{Molins2009IdentificationOF,
  title={Identification of Francisella tularensis subsp. tularensis A1 and A2 infections by real-time polymerase chain reaction.},
  author={Claudia R Molins and Jennifer K. Carlson and Jana Coombs and Jeannine M. Petersen},
  journal={Diagnostic microbiology and infectious disease},
  year={2009},
  volume={64 1},
  pages={6-12}
}
Francisella tularensis subsp. tularensis (type A) is subdivided into clades A1 and A2. Human tularemia infections caused by A1 and A2 differ with respect to clinical outcome; A1 infections are associated with a higher case fatality rate. In this study, we develop and evaluate TaqMan polymerase chain reaction (PCR) assays for identification of A1 and A2. Both assays were shown to be specific to either A1 or A2, with sensitivities of 10 genomic equivalents. Real-time PCR results for… CONTINUE READING
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Canonical insertiondeletion markers for rapid DNA typing of Francisella tularensis

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