Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages

@inproceedings{Woolard2013IdentificationOF,
  title={Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages},
  author={Matthew D. Woolard and Lydia M. Barrigan and James Robertson Fuller and Adam S. Buntzman and Joshua D. Bryan and Colin S Manoil and Thomas H Kawula and Jeffrey A Frelinger},
  booktitle={Front. Microbio.},
  year={2013}
}
Francisella tularensis is the causative agent of tularemia. We have previously shown that infection with F. tularensis Live Vaccine Strain (LVS) induces macrophages to synthesize prostaglandin E(2) (PGE(2)). Synthesis of PGE(2) by F. tularensis infected macrophages results in decreased T cell proliferation in vitro and increased bacterial survival in vivo. Although we understand some of the biological consequences of F. tularensis induced PGE(2) synthesis by macrophages, we do not understand… CONTINUE READING
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