Identification of Fc epsilon RIneg mast cells in mouse bone marrow cell cultures. Use of a monoclonal anti-p161 antibody

@article{Kinzer1995IdentificationOF,
  title={Identification of Fc epsilon RIneg mast cells in mouse bone marrow cell cultures. Use of a monoclonal anti-p161 antibody},
  author={C A Kinzer and Achsah D. Keegan and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={182},
  pages={575 - 579}
}
A monoclonal hamster antibody (K-1) specific for a 161-kD mast cell surface glycoprotein was derived. p161 is expressed on normal and cultured mast cells and on some macrophages, but not on basophils or other hematopoietic cells. A population of Fc epsilon Rneg cells expressing p161 was found in short term cultures of bone marrow cells grown in interleukin (IL)-3. These cells were purified and propagated for extended periods in IL-3. They express c-kit and Fc gamma RII/III, contain alcian blue… CONTINUE READING

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