Identification of Fat Storage-Inducing Transmembrane Proteins 1 and 2 as Putative Therapeutic Targets for Heart Failure by Integrated Analysis of Proteome and Transcriptome

@article{Nishihama2018IdentificationOF,
  title={Identification of Fat Storage-Inducing Transmembrane Proteins 1 and 2 as Putative Therapeutic Targets for Heart Failure by Integrated Analysis of Proteome and Transcriptome},
  author={Natsumi Nishihama},
  journal={Journal of Proteomics \& Bioinformatics},
  year={2018},
  volume={11}
}
Cardiovascular disease constitutes a major health burden globally, for which novel cardiotonic agents are still required. Cardiac failure is thought to be caused by dysfunctions of the sarcoplasmic/endoplasmic reticulum (SR/ ER) in cardiomyocytes. Therefore, in this study, we searched for novel pharmaceutical targets in SR/ER. Tissue and organelle specific proteome profiling by liquid chromatography coupled with mass spectrometry after gel electrophoresis separation identified 3,638 proteins in… 

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