Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling

  title={Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling},
  author={Hendrik J. Kuiken and David A. Egan and Heike Laman and Ren{\'e} Bernards and Roderick Leonardus Beijersbergen and Annette M. G. Dirac},
  booktitle={Journal of cellular and molecular medicine},
The nuclear factor κB (NF-κB) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is highly dependent on ubiquitination events. Using cytoplasmic to nuclear translocation of the NF-κB transcription factor family member p65 as a read-out, we screened a synthetic siRNA library targeting enzymes involved in ubiquitin conjugation and de-conjugation for modifiers… CONTINUE READING
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