Identification of Essential Proteins Based on Edge Clustering Coefficient

@article{Wang2012IdentificationOE,
  title={Identification of Essential Proteins Based on Edge Clustering Coefficient},
  author={Jianxing Wang and Min Li and Huan Wang and Yi Pan},
  journal={IEEE/ACM Transactions on Computational Biology and Bioinformatics},
  year={2012},
  volume={9},
  pages={1070-1080}
}
Identification of essential proteins is key to understanding the minimal requirements for cellular life and important for drug design. The rapid increase of available protein-protein interaction (PPI) data has made it possible to detect protein essentiality on network level. A series of centrality measures have been proposed to discover essential proteins based on network topology. However, most of them tended to focus only on the location of singleprotein, but ignored the relevance between… CONTINUE READING
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