Identification of Essential Histidine Residues Involved in Heme Binding and Hemozoin Formation in Heme Detoxification Protein from Plasmodium falciparum

@inproceedings{Nakatani2014IdentificationOE,
  title={Identification of Essential Histidine Residues Involved in Heme Binding and Hemozoin Formation in Heme Detoxification Protein from Plasmodium falciparum},
  author={Keisuke Nakatani and Haruto Ishikawa and Shigetoshi Aono and Yasuhisa Mizutani},
  booktitle={Scientific reports},
  year={2014}
}
Malaria parasites digest hemoglobin within a food vacuole to supply amino acids, releasing the toxic product heme. During the detoxification, toxic free heme is converted into an insoluble crystalline form called hemozoin (Hz). Heme detoxification protein (HDP) in Plasmodium falciparum is one of the most potent of the hemozoin-producing enzymes. However, the reaction mechanisms of HDP are poorly understood. We identified the active site residues in HDP using a combination of Hz formation assay… CONTINUE READING
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