Identification of Escherichia coli outer membrane protein A receptor on human brain microvascular endothelial cells.

@article{Prasadarao2002IdentificationOE,
  title={Identification of Escherichia coli outer membrane protein A receptor on human brain microvascular endothelial cells.},
  author={Nemani V. Prasadarao},
  journal={Infection and immunity},
  year={2002},
  volume={70 8},
  pages={4556-63}
}
Neonatal Escherichia coli meningitis continues to be a diagnostic and treatment challenge despite the availability of active antibiotics. Our earlier studies have shown that outer membrane protein A (OmpA) is one of the major factors responsible for Escherichia coli traversal across the blood-brain barrier that constitutes a lining of brain microvascular endothelial cells (BMEC). In this study we showed that OmpA binds to a 95-kDa human BMEC (HBMEC) glycoprotein (Ecgp) for E. coli invasion… CONTINUE READING