Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension: Novel Effects of an Old Drug.

@article{Siddique2018IdentificationOE,
  title={Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension: Novel Effects of an Old Drug.},
  author={Mohammad AbdulHai Siddique and Kimio Satoh and Ryo Kurosawa and Nobuhiro Kikuchi and Md. Elias-Al-Mamun and Junichi Omura and Taijyu Satoh and Masamichi Nogi and Shinichiro Sunamura and Satoshi Miyata and Hirofumi Ueda and Hidetoshi Tokuyama and Hiroaki Shimokawa},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2018},
  pages={
          ATVBAHA119313309
        }
}
OBJECTIVE Excessive proliferation and apoptosis resistance are special characteristics of pulmonary artery smooth muscle cells (PASMCs) in pulmonary arterial hypertension (PAH). However, the drugs in clinical use for PAH target vascular dilatation, which do not exert adequate effects in patients with advanced PAH. Here, we report a novel therapeutic effect of emetine, a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug. Approach and Results… CONTINUE READING