Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.

@article{Kokame2001IdentificationOE,
  title={Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.},
  author={Koichi Kokame and Hisakazu Kato and Toshiyuki Miyata},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 12},
  pages={9199-205}
}
Herp is a 54-kDa membrane protein in the endoplasmic reticulum (ER). The mRNA expression level of Herp is increased by the accumulation of unfolded proteins in the ER. Transcriptional changes designed to deal with this type of ER stress is called the unfolded protein response (UPR). Most mammalian UPR-target genes encode ER-resident molecular chaperones: GRP78, GRP94, and calreticulin. The promoter regions of these genes contain a cis-acting ER stress response element, ERSE, with the consensus… CONTINUE READING

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