Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer.

@article{Nielsen2002IdentificationOE,
  title={Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer.},
  author={Helga Lind Nielsen and Lone R\onnov-Jessen and Ren{\'e} Villadsen and Ole William Petersen},
  journal={Genomics},
  year={2002},
  volume={79 5},
  pages={703-10}
}
During growth, invasion, and metastasis, tumor cells interact extensively with the surrounding stroma. To identify genes that are upregulated during this process, we compared mRNA pooled from tumor cells and fibroblasts cultured separately to mRNA from cells in coculture. Using differential display (DD), a transcript representing a novel gene, designated epithelial-stromal interaction 1 (breast) (EPSTI1), was identified. EPSTI1 showed no homology to any known gene, but matched a cluster of… CONTINUE READING

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